Search on: THYMIDYLATE SYNTHASE 
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Descriptor English:   Thymidylate Synthase 
Descriptor Spanish:   Timidilato Sintasa 
Descriptor Portuguese:   Timidilato Sintase 
Synonyms English:   Synthase, Thymidylate
Synthetase, Thymidylate
Thymidylate Synthetase  
Tree Number:   D08.811.913.555.500.862
Definition English:   An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45. 
History Note English:   98; see METHYLTRANSFERASES 1975-85 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   14327 
Unique Identifier:   D013940 

Occurrence in VHL:
 

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